Barretts syndrome (inflammation of the esophagus)

Throat | Gastroenterology | Barretts syndrome (inflammation of the esophagus) (Disease)


Barrett esophagus also known by the names of Barrett syndrome or columnar epithelium lined lower oesophagus (CELLO) is a medical condition that relates to an abnormal change named metaplasia in the cells of the inferior portion of the esophagus.

Barrett esophagus is associated with the following symptoms: frequent and longstanding heartburn, trouble swallowing known as dysphagia, vomiting blood called hematemesis, pain under the breastbone where the esophagus meets the stomach, unintentional weight loss because eating is painful. Both macroscopic and microscopic positive findings are required to make a diagnosis. While Barretts syndrome may cause no symptoms itself, some people with this condition develop a rare, but often deadly, type of esophageal cancer called esophageal adenocarcinoma.

Causes and Risk factors

Barrett esophagus is the cause of chronic inflammation. Barretts esophagus is a complication of chronic gastroesophageal reflux disease (GERD), primarily in white men. GERD is a disease in which there is reflux of acidic fluid from the stomach into the esophagus (the swallowing tube). It most commonly causes heartburn.

Diagnosis and Treatment

Although there is no cure for Barretts syndrome, there are several treatment options available, such as Gastroesophageal reflux disease medication or surgery. Proton pump inhibitor drugs have not yet been proven to prevent esophageal cancer. Laser treatment is used in severe dysplasia, while overt malignancy may require surgery, radiation therapy, or systemic chemotherapy. ...