Intrahepatic cholestasis of pregnancy

Abdomen | Gastroenterology | Intrahepatic cholestasis of pregnancy (Disease)


Intrahepatic cholestasis of pregnancy (ICP) is an uncommon liver disorder involving generalized itching, often commencing with pruritus of the palms of the hands and soles of the feet. It most often presents in the late second or early third trimester of pregnancy.

Causes and Risk factors

ICP has no clear etiology, and it is believed to be a multifactorial disorder with environmental, hormonal, and genetic contributions.

Diagnosis and Treatment

The diagnosis is based on physical and laboratory findings, but in general, ICP is a diagnosis of exclusion. Once the diagnosis of ICP is made, treatment should be initiated immediately. Maternal outcomes for patients diagnosed with ICP are good, with few, if any, long-term sequelae; however, fetal outcomes can be devastating. Thus, early recognition, treatment, and timely delivery are imperative. ...

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