Premature ovarian failure

Pelvis | Gynecology | Premature ovarian failure (Disease)


Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (this is the most accurate term as some women may still conceive) or premature menopause, is the loss of function of the ovaries before age 40.

Causes and Risk factors

A commonly cited triad for the diagnosis is amenorheea, hypergonadotropinism and hypoestrogenism. If it has a genetic cause, it may be called gonadol dysgenesis. The cause of POF is usually idiopathic.

Some cases of POF are attributed to autoimmune disorders, others to genetic disorders such as Turner syndrome and Fragile X syndrome. Family history and ovarian or other pelvic surgery earlier in life are also implicated as risk factors for POF.

Diagnosis and Treatment

Estrogen is given to prevent osteoporosis and treat the hot flashes and emotional symptoms of the disorder. The estrogen can be given as a pill, patch, cream or through a vaginal ring. Progesterone is commonly prescribed along with the estrogen. Calcium and vitamin D are given as well. Unfortunately these treatments typically do not reverse the infertility. A small subset of patients who have persistent fatigue and low sex drive may be given male hormones (androgens). ...

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