Astellas Pharma | Amevive (Medication)


Amevive is used for the treatment of moderate to severe chronic plaque psoriasis in people who are candidates for systemic therapy or phototherapy.

Amevive is an injectable drug that suppresses the immune system.

Scientists believe that psoriasis is caused by an increase in the production of one type of immune cell, T-lymphocytes, in response to the attachment of a stimulant (antigen) to the lymphocyte.

It reduces the stimulation and production of T-lymphocytes by attaching to the site on the T-lymphocytes where the antigen attaches. This prevents the antigen from binding and activating the T-lymphocytes. Alefacept also decreases the life-span of T-lymphocytes that already have been produced by increasing the activity of another type of immune cell, natural killer cells, that kill T-lymphocytes. ...

Side Effect:

Common side effects persist or become bothersome when using Amevive:dizziness; increased cough; muscle aches or pain; nausea; pain or swelling at the injection site; sore throat or throat inflammation.

Seek medical attention right away if any of the following severe side effects occur when using Amevive:severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; chills; fever; new or altered skin lesions or spots; painful or frequent urination; persistent sore throat; serious infections; swollen glands; unusual lumps; unusual vaginal discharge; white patches in the mouth (oral thrush). ...


Prior to using this medicine tell your healthcare provider if you have any type of allergies. Inform your doctor if you have any of the following conditions:have heart or blood vessel problems; have cancer or a history of cancer; have an infection or a history of chronic infection; or are taking another immunosuppressive medication or are receiving phototherapy.

Talk to your doctor before taking Amevive if you are HIV positive. You may not be able to use Amevive.

During pregnancy and breastfeeding is not recommended to use this medicine without your doctor's advice. ...