Amifostine - injection

Unknown / Multiple | Amifostine - injection (Medication)


Amifostine is used protect the kidneys against the harmful effects of the cancer-fighting drug cisplatin in patients with ovarian cancer or lung cancer. It is also used to help prevent a certain side effect (dry mouth) caused by radiation treatment for head and neck cancer. Amifostine is thought to work by preventing certain chemicals from damaging healthy cells. It may also help repair cells damaged by cisplatin or radiation treatment.

Amifostine is in a class of drugs known as chemoprotectants; it protects against the harmful effects of cisplatin and radiation treatment. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have. ...

Side Effect:

Some of the side effects include:allergic reaction:itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing; blistering, peeling, or red skin rash; chest pain; fast, slow, or uneven heartbeat; fever or chills; red skin lesions on the palms of the hands or soles of the feet; severe nausea or vomiting; sores or white patches on your lips, mouth, or throat; sudden dizziness or lightheadedness; swelling in your hands, ankles, or feet; unusual tiredness or weakness.

Other less serious side effects may include:less serious side effects, talk with your doctor:blurred vision, pain, itching, burning, swelling, or a lump under your skin where the needle is placed, unusual drowsiness or sleepiness, warmth or redness in your face, neck, arms, or upper chest.



Patients should be adequately hydrated prior to the Amifostine infusion and blood pressure should be monitored. The safety of Amifostine administration has not been established in elderly patients, or in patients with preexisting cardiovascular or cerebrovascular conditions such as ischemic heart disease, arrhythmias, congestive heart failure, or history of stroke or transient ischemic attacks. Amifostine should be used with particular care in these and other patients in whom the common Amifostine adverse effects of nausea/vomiting and hypotension may be more likely to have serious consequences.

Prior to chemotherapy, Amifostine should be administered as a 15-minute infusion. Blood pressure should be monitored every 5 minutes during the infusion, and thereafter as clinically indicated. Prior to radiation therapy, Amifostine should be administered as a 3-minute infusion. Blood pressure should be monitored at least before and immediately after the infusion, and thereafter as clinically indicated. ...