Anistreplase - injection

Sigma Pharmaceuticals | Anistreplase - injection (Medication)


Anistreplase-injection is used in acute MI for lysis of coronary artery thrombi. This medication prevents blood from clotting. Studies have shown this medication to be effective in reducing the risk of death following an acute heart attack.

This medication is given by injection into a vein as soon as possible after heart attack symptoms occur. It will be given by a health care professional who will closely monitor your therapy. Increased risk of haemorrhage with heparin, oral anticoagulants, antiplatelet drugs and other drugs that can affect platelet function. ...

Side Effect:

Adverse effects of this drug include headache, fever, sweating, agitation, dizziness, paresthesia, tremor, vertigo, hypotension, conduction disorders, nausea, vomiting, decreased hematocrit, surface bleeding, rash, urticaria, phlebitis at the injection site, itching, flushing, low back pain, arthralgia, altered respirations, and dyspnea.

Life-threatening side effects include intracranial hemorrhage, dysrhythmias, GI bleeding, genitourinary bleeding, intracranial bleeding, retroperitoneal bleeding, thrombocytopenia, bronchospasm, lung edema, and anaphylaxis.



This drug should not be used when the following conditions are present:bleeding, blood vessel abnormalities, brain tumor, history of stroke, recent surgery, extremely high blood pressure (200/120 or higher).

This drug should be used with caution when the following conditions exist:childbirth within the last 10 days, blood clotting problems, endocarditis, recent retinal bleeding, recent gastrointestinal or urinary tract bleeding, ulcers, very high blood pressure (180/110), a recent invasive procedure, if you have ever had a synthetic graft placed (knitted Dacron), heart abnormalities. This medication should be used during pregnancy only if clearly needed. Risks and benefits should be discussed with your doctor. ...