Schering-Plough | Asenapine (Medication)


Asenapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain. Asenapine is used in acute treatment of adults with schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features in adults. Asenapine is used alone or in combination with other medications to treat or prevent episodes of mania (frenzied, abnormally excited mood) or mixed mania (frenzied, abnormally excited mood and symptoms of depression) in people with bipolar I disorder (manic depressive disorder; a disease that causes episodes of mania, episodes of depression and other abnormal moods).

Asenapine comes as a sublingual tablet to dissolve under the tongue. It is usually taken twice a day. Asenapine should be taken at around the same times every day. ...

Side Effect:

Stop using asenapine and call your doctor at once if you have any of these serious side effects:very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out; twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; tremor (uncontrolled shaking); trouble swallowing; sudden numbness or weakness, especially on one side of the body; sudden and severe headache, or problems with vision, speech, or balance; easy bruising or bleeding, fever, chills, body aches, flu symptoms; white patches or sores inside your mouth or on your lips; seizure (convulsions); or unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself.

Less serious side effects may include:dizziness, drowsiness; restless feeling; numbness or tingling inside or around your mouth; constipation; dry mouth; sleep problems (insomnia); upset stomach; or weight gain.

Seek immediate medical help if you have any of these signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat. ...


Prior to taking this medication inform your doctor if you have any type of allergies. Asenapine is not for use in psychotic conditions related to dementia. Asenapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Inform your doctor if you have any of these other conditions:liver disease; heart disease, high blood pressure, heart rhythm problems; a history of heart attack or stroke; a history of breast cancer; seizures or epilepsy; diabetes (asenapine may raise your blood sugar); trouble swallowing; Parkinson's disease; a history of low white blood cell (WBC) counts; or a personal or family history of Long QT syndrome.

During pregnancy and breastfeeding is not recommended to use this medicine without your doctor's advice. ...