Genentech | Actimmune (Medication)


This medication is used to reduce the frequency and severity of serious infections due to chronic granulomatous disease, a disorder that runs in families. This drug is often used along with antibiotics to help prevent these serious infections. Actimmune is also used to slow the worsening of malignant osteopetrosis, another disorder that runs in families, that affects bones, nerves, and blood. This medication is the same as a protein that your body naturally produces (interferon). In the body, it is thought to work by affecting cell function/growth and the body's natural defenses (immune system) in many ways. Adding more interferon may help your body fight off serious infections.

Actimmune/interferon gamma 1 b is a sterile, clear, colorless solution filled in a single-use vial for subcutaneous injection. Each 0. 5 mL of Actimmune contains:100 mcg (2 million IU) of Interferon gamma-1 b formulated in 20 mg mannitol, 0. 36 mg sodium succinate, 0. 05 mg polysorbate 20 and sterile water for Injection. ...

Side Effect:

Contact your doctor at once if you have any of these serious side effects:fever, chills, body aches, flu symptoms; easy bruising or bleeding, unusual weakness; feeling light-headed, fainting; fast or uneven heart rate; or sudden numbness or weakness, especially on one side of the body.

Less serious side effects may include:problems with memory or concentration; weakness, tired feeling, lack of coordination; pain or redness where the injection was given; nausea, vomiting, diarrhea; muscle or joint pain; or headache.

Get immediate medical help if you have any of these signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat. ...


Before using Actimmune, tell your doctor or pharmacist if you are allergic to interferon or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:heart disease (e. g. , angina, irregular heartbeat, congestive heart failure), liver disease, seizure disorder, blood cell disorders (e. g. , anemia, neutropenia, thrombocytopenia).

Actimmune/interferon gamma - 1b affects your immune system so it may increase your risk of developing a serious infection. Talk to your healthcare provider about the risks of using this medication.

Children, especially those younger than 1 year, may be at greater risk for effects on the liver while using this drug. The manufacturer recommends regular laboratory tests (liver function tests), especially in children younger than 1 year.

During pregnancy and breastfeeding is not recommended to use this medicine without your doctor's advice. ...