Genentech | Activase (Medication)


Activase (Alteplase) is a tissue plasminogen activator produced by recombinant DNA technology. It is a sterile, purified glycoprotein of 527 amino acids.

Activase is used for treating blood clots in the lungs and improving heart function and survival following a heart attack. Activase may also be used to improve recovery and reduce disability in certain patients who have had a stroke. It may also be used for other conditions as determined by your doctor.

The indications for Activase are:management of acute myocardial infarction to improve ventricular function and reduce the incidence of CHF and mortality. Management of acute ischemic stroke to improve neurologic recovery and reduce disability. Management of acute massive pulmonary embolism. ...

Side Effect:

When used in small doses, no common side effects have been reported with this product.

Seek medical attention right away if any of these severe side effects occur:severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; bloody vomit; calf pain or tenderness; changes in vision; chest pain; chills; coughing up blood; difficulty breathing or sudden shortness of breath; fast, slow, or irregular heartbeat; fever; one-sided weakness; redness, swelling, or pain at the catheter site; severe bleeding; severe stomach pain; speech problems or changes; unusual or easy bleeding or bruising. ...


Standard management of myocardial infarction or pulmonary embolism should be implemented concomitantly with Activase treatment. Noncompressible arterial puncture must be avoided and internal jugular and subclavian venous punctures should be avoided to minimize bleeding from noncompressible sites. Arterial and venous punctures should be minimized.

In the event of serious bleeding, Activase and heparin should be discontinued immediately. Heparin effects can be reversed by protamine. Additional monitoring of your dose or condition may be needed if you are taking warfarin or aspirin. ...