Takeda Pharmaceutical Company | Actos (Medication)


Actos is a medicine containing the active substance pioglitazone, which is indicated as second or third line treatment of type 2 diabetes mellitus. Type 2 diabetes a condition where the pancreas does not produce enough insulin to control blood glucose concentration.

Pioglitazone, the active ingredient in Actos, makes the cells more sensitive to insulin, which means that the body makes better use the insulin it produce, reducing glucose concentration and controlling type 2 diabetes is facilitated. ...

Side Effect:

The most common side effects of Actos data are visual disturbances, upper respiratory tract infections (colds), weight gain and hypoesthesia (decreased sensitivity to stimuli). The types of side effects reported when pioglitazone was used in combination with sulfonylurea, metformin or insulin were generally similar to those reported during pioglitazone monotherapy with the exception of an increase in the occurrence of edema in the insulin combination study.

Actos has been generally well tolerated with the incidence of adverse effects similar to placebo. Upper respiratory tract infections, headache, sinusitis, myalgia, tooth disorder and pharyngitis were reported slightly more frequently than placebo in clinical trials. ...


Do not take Actos if you are hypersensitive (allergic) to pioglitazone or any of the other ingredients of Actos; heart failure in the past; liver disease; diabetic ketoacidosis (a complication of diabetes causing rapid weight loss nausea or vomiting); had bladder cancer; blood in your urine that your doctor has not checked.

Tell your doctor before you start to take this medicine if you retain water or have heart failures problems in particular if you are over 75 years old; special type of diabetic eye disease called macular oedema (swelling of the back of the eye); if you have cysts on your ovaries (polycystic ovary syndrome); a problem with your liver or heart.

If you take Actos with other medicines for diabetes, it is more likely that your blood sugar could fall below the normal level (hypoglycaemia). ...