Galderma Laboratories | Adapalene (Medication)


Adapalene is a gel used for the treatment of acne vulgaris (pimples). The exact mechanism of action is not known. Scientists believe that when adapalene is applied to the skin, and appears to bind with specific receptors in skin cells in a way that encourages the formation of normal skin cells and discourages the formation of acne lesions.

There may be a worsening of acne during the first few weeks of therapy because adapalene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Beneficial effects should be seen by 8 to 12 weeks. ...

Side Effect:

Serious side effects are rare and not likely to occur. However if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives) seek medical help immediately.

The most common side effects of adapalene are irritation, redness, dryness, and itching of the skin as well as flares of acne. Most of these side effects lessen with continued use; however, if they are bothersome, decreasing the frequency with which adapalene is applied may reduce these side effects. ...


Adapalene may increase the sensitivity of the skin to sun and lead to sunburn. Excessive sun exposure should be avoided, and sunscreens should be used over the treated areas if exposure to the sun cannot be avoided. Adapalene should not be applied to sunburned skin, cuts, eyes, nose, or lips.

Tell your doctor and pharmacist if you are allergic to adapalene or any other medications. Inform your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or using.

Many skin care products can irritate your skin if you use them with adapalene. This is especially likely if you use products that are harsh, dry out the skin, or contain alcohol, spices, lime rind, sulfur, resorcinol, salicylic acid, or alpha hydroxy acid.

Your doctor should be informed if you have or have ever had eczema or cancer or if you are pregnant, plan to become pregnant, or are breast-feeding. ...